The FDA required Bristol-Myers Squibb to add two black box warnings to the medication’s packaging. But the FDA cleared large scale production of Portola Pharmaceuticals’ antidote, Andexxa, to begin in January 2019. The drug’s label mentions two trials in which the most common reason for stopping the drug was severe bleeding, or hemorrhaging.įor about six years, apixaban users did not have an approved remedy for internal bleeding. Serious and potentially life-threatening bleeding is the most severe side effect. Minor side effects include bruising more easily and minor bleeding that takes longer than usual to stop. More than 1 percent of patients who took the drug in clinical trials reported the issues. Common and Serious Side EffectsĪccording to the drug’s label, the most common side effects of Eliquis are related to bleeding. Patients should never stop taking a prescription drug without the supervision of a doctor. People should stop taking the drug 48 hours prior to any surgery that has a moderate to high risk of bleeding and at least 24 hours prior to surgeries with a low risk of bleeding, according to the drug’s label. But you should never double up on a dose if you miss one. If for some reason you do not take a dose at the scheduled time, try to take the dose as soon as possible. Patients who have taken apixaban for at least six months to treat DVT or PE may be instructed to continue taking 2.5 mg of the drug twice a day to reduce the risk of the blood clots forming again. After that, the drug label recommends doctors decrease the dose to 5 mg twice a day. The recommended dosage in patients who have suffered DVT or PE is 10 mg taken twice daily for seven days. They should continue to take the medication for about 35 days after a hip replacement and for about 12 days after a knee replacement. Patients should take the first dose 12 hours to 24 hours after the surgery, according to the drug’s label. A smaller, twice daily 2.5 mg dose is recommended for atrial fibrillation patients with any two of the following characteristics:īlood levels of creatinine at 1.5 mg/dL or greaterĭoctors may also prescribe twice daily 2.5 mg doses to prevent DVT after a hip or knee replacement. The most commonly prescribed dosage for patients with atrial fibrillation is 5 mg taken twice a day. In May 2018, the FDA approved the first antidote to stop rare, uncontrolled bleeding caused by the medication.Įliquis comes in 2.5 mg and 5 mg oral tablets. The FDA warns these medicines can cause serious, potentially fatal bleeding.Įliquis’ effects last for at least 24 hours after the last dose, according to the drug’s label. The drug is the latest in a new class of anticoagulants that includes Pradaxa (dabigatran etexilate) and Xarelto (rivaroxaban). The medication works by blocking Factor Xa, which is a key enzyme in the blood clotting process. Food and Drug Administration approved apixaban to not only treat DVT and PE, but also to lower the chance of the blood clots forming again.īristol-Myers Squibb manufactures Eliquis. This life-threatening condition is called pulmonary embolism, or PE. Left untreated, these blood clots can travel and become lodged in arteries that go from the heart to the lungs. About Įliquis (apixaban) is a prescription anticoagulant, or blood thinner, used to lower the risk of strokes and blood clots in people with an irregular heartbeat known as atrial fibrillation.ĭoctors also prescribe the drug to people after knee or hip replacement surgery to prevent deep vein thrombosis, or DVT, which is when blood clots form in veins deep in the body.
#Antidote for eliquis professional#
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